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SPA
+++++ Software Publishers Association
++--- special protection area
+---- special psychological opera
AcroLexic: Dictionary of Acronyms and Abbreviations contains 32 more definitions of “SPA”.
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See also

Acronym Definitions
SPAR 17
SPAC 12
SPAN 11
SPARC 9
SPACE 8
SPAD 5
SPAS 5
SPAG 4
SPADE 4
ASPA 3
ISPA 3
SPAM 3
SPARS 3
SPADS 3
SPACECOM 3
SPAP 2
SPACETRACK 2
COSPAS 2
SPASUR 2
SPADOC 2