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LES
++/-- lower esophageal sphincter
+/--- large eddy simulations
+/--- large-eddy simulation
AcroLexic: Dictionary of Acronyms and Abbreviations contains 15 more definitions of “LES”.
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See also

Acronym Definitions
MILES 4
LESS 2
ARISTOTELES 1
DLESE 1
LEST 1
POLES 1